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The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal painin the general adult US population by means of randomised controlled trials (RCTs) (Table 3). RCTs are designed to measure the effectiveness of an intervention, and are designed to demonstrate the use of an intervention before an adverse event has occurred or after the intervention has been discontinued.In a large RCT published in 1995, 757 patients with severe, painful-limb pain were randomly assigned to receive NSAID (50 mg twice daily) or placebo. An 8-week secondary analysis found that NSAID injections were more effective at relieving pain than conventional therapies, as estimated by the ratio of the odds of a pain-free 8-week follow-up to the odds of needing NSAID (0, androx 400 review.65 for NSAID, 1, androx 400 review.26 for placebo; P < 0, androx 400 review.001), androx 400 review.17Other RCTs have shown similar results. A RCT by Strom et al found that NSAIDs were significantly more effective at improving pain than placebo treatments, with an odds ratio for NSAID use after 8 weeks of 0.75 (95% confidence interval [CI], 0.69 to 0.83) compared with 0.53 (0.46 to 0.64) for placebo, P < 0.001.17 The results of this RCT were used to compare NSAID with the no-treatment control group.22 The results of a double-blind, randomised, controlled trial by Chappell et al reported similar results.23The meta-analysis of RCTs has shown that these findings are robust and that NSAID were significantly more effective at relieving pain than conventional therapies, with an odds ratio for NSAID use after 8 weeks of 0, oral steroids multiple sclerosis.62 (95% CI, 0, oral steroids multiple sclerosis.50 to 0, oral steroids multiple sclerosis.74) compared with 0, oral steroids multiple sclerosis.46 (0, oral steroids multiple sclerosis.39 to 0, oral steroids multiple sclerosis.51) for placebo, P = 0, oral steroids multiple sclerosis.02, oral steroids multiple sclerosis.17,17 In summary, RCTs by Chappell and others found that NSAIDs were more effective than conventional therapies for relieving painful-limb pain in the general adult population, oral steroids multiple sclerosis.14 This suggests that the benefits associated with NSAID use are independent of pain and associated with improved functioning in the general population, oral steroids multiple sclerosis.Other RCTs have shown that NSAIDs were not significantly more effective than placebo at reducing the risk of musculoskeletal pain (Table 4)24 and that NSAIDs do not reduce pain in patients who require knee arthroplasty or prosthetic replacement, androx 400 review.25,26 In a series of four
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